Trials / Completed
CompletedNCT00876616
Assess the Efficacy and Safety of Multi-target Therapy in Lupus Nephritis
An Multi-site, Open, Prospective Study to Assess the Efficacy and Safety of Multi-target Therapy in the Treatment of Class Ⅲ,Ⅳ,Ⅴ,Ⅲ+Ⅴand Ⅳ+Ⅴ Lupus Nephritis
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 362 (actual)
- Sponsor
- Zhi-Hong Liu, M.D. · Academic / Other
- Sex
- All
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to assess the efficacy and safety of multi-target therapy in the treatment of class Ⅲ,Ⅳ,Ⅴ,Ⅲ+Ⅴand Ⅳ+Ⅴ lupus nephritis.
Detailed description
1. To assess the efficacy of FK506 combined with MMF vs intravenous cyclophosphamide (CTX) pulses in treatment of class Ⅲ,Ⅳ,Ⅴ,Ⅲ+Ⅴand Ⅳ+Ⅴ Lupus Nephritis (LN). 2. To investigate the safety and tolerability of FK506 combined with MMF vs intravenous CTX pulses in the treatment of class Ⅲ,Ⅳ,Ⅴ,Ⅲ+Ⅴand Ⅳ+Ⅴ LN.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Tacrolimus+Mycophenolate mofetil | FK506 4mg/d,MMF 1.0g/d |
| DRUG | Cyclophosphamide | CTX 0.75g/m2 BSA |
Timeline
- Start date
- 2009-04-01
- Primary completion
- 2011-05-01
- Completion
- 2012-02-01
- First posted
- 2009-04-07
- Last updated
- 2013-08-29
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT00876616. Inclusion in this directory is not an endorsement.