NCT00870025

Human Chorionic Gonadotropin (hCG) Priming Prior to Controlled Ovarian Hyperstimulation (COH) in Poor Responder In Vitro Fertilization (IVF) Patients

hCG Priming Prior to COH in Poor Responder IVF Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: IVI Madrid · Academic / Other
• Sex: Female
• Age: 18 Years – 41 Years
• Healthy volunteers: Not accepted

Summary

There is a decline in androgen concentration with ovarian aging. Also, ovarian response to COH in IVF cycles diminishes with ovarian aging. Recent evidence suggest that testosterone or DHEA may improve ovarian response in poor prognosis patients by increasing intraovarian androgen concentration. A physiological way to induce androgen synthesis within the ovary is to stimulate theca cells androgen production by hCG stimulation. By doing this in the previous cycle we might expect a better response to COH.

Conditions

• Ovarian Response

Interventions

Type	Name	Description
BIOLOGICAL	human chorionic gonadotropin	200 IU, sc, every 5 days, 4 doses
BIOLOGICAL	placebo	diluent, every 5 days, s.c., 4 doses

Timeline

• Start date: 2008-10-01
• Primary completion: 2010-09-01
• Completion: 2010-09-01
• First posted: 2009-03-26
• Last updated: 2015-04-22

Locations

1 site across 1 country: Spain