NCT00869453

Gut Hormone Secretion and Macronutrients

Gut Hormone Secretion Pattern in Response to Different Macronutrients in Healthy Volunteers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 8 (actual)
• Sponsor: University of Lausanne · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The role of gut hormone (GLP-1, GIP, PYY...) in glucose homeostasis has been widely demonstrated. Furthermore modifications in their pattern of secretion seem to be involved in the improvement of glucose control in obese patients after bariatric surgery. The purpose of this study is to assess the respective role of carbohydrate, fat and protein from a complete meal in gut hormones secretion.

Detailed description

The study is designed to asses the role of each individual macronutrient of a compete meal in gut hormones secretion in healthy volunteers. 8 healthy young male subjects will be studied on 5 different occasions. To asses the role of each macronutient the subjects will recieve one of the following test meal: a complete sandwich, the proteic part of this complete meal, the glucidic part and the lipidic part. The fifth test will be a fasting test. To assess the entero-insular axis, a 5.5 hours hyperglycaemic clamp will be performed.

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
OTHER	test meal	Mixed meal containing bread, butter, beef
OTHER	glucose	administration of a glucose meal
OTHER	fat	administration of a lipid meal
OTHER	protein	administration of a protein meal
OTHER	control	no meal

Timeline

• Start date: 2009-03-01
• Primary completion: 2009-08-01
• Completion: 2009-12-01
• First posted: 2009-03-26
• Last updated: 2012-07-03

Locations

2 sites across 1 country: Switzerland