NCT00869427

Vitamin C for Prevention of Urinary Tract Infections in the Spinal Cord Injured

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Sunnaas Rehabilitation Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

After spinal cord injury, patients have frequent urinary tract infections (UVI). Vitamin C is usually prescribed to prevent such infection, but the efficacy of the treatment is poorly documented. In the study, patients will be randomised either to receive vitamin C daily, or not, for one year, and clinical episodes of UVI will be registered. The null hypothesis is that vitamin C will not reduce the number of UVI episodes by 30%.

Detailed description

The study is an investigator-blind randomised parallel study on the efficacy of vitamin C to prevent urinary tract infections in stable, ambulatory spinal cord-injured patients. To be included, patients should have had at least 3 previous UVI episodes over the last two years. 40 patients are included. Patients are randomised to receive either 1 g vitamin C b.i.d. over 1 year, or no vitamin C. The main outcome is the number of clinical UVIs that have been treated with antibiotics.

Conditions

• Urinary Tract Infection
• Spinal Cord Injury

Interventions

Type	Name	Description
DRUG	vitamin C	vitamin C 1g bid for 1 year

Timeline

• Start date: 2009-03-01
• Primary completion: 2011-06-01
• Completion: 2011-06-01
• First posted: 2009-03-26
• Last updated: 2010-07-05