NCT00868933

Low Glycemic Index Dietary Intervention Program in Nonalcoholic Fatty Liver Disease

Low Glycemic Index Dietary Intervention Program in Nonalcoholic Fatty Liver Disease - A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 159 (actual)
• Sponsor: Chinese University of Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in affluent countries. It may progress to cirrhosis and liver cancer. At present, there is no approved drug for NAFLD. Although healthy diet and exercise is often recommended, there is little supportive evidence. Therefore, the investigators plan to conduct a randomized controlled trial comparing a low glycemic index dietary intervention program and simple lifestyle advice in NAFLD patients. The primary endpoint is resolution of NAFLD. Non-invasive tests will be used to assess the study subjects. Proton-magnetic resonance spectroscopy is used to quantify hepatic triglyceride content, and transient elastography is used to quantify liver fibrosis.

Conditions

• Nonalcoholic Fatty Liver Disease

Interventions

Type	Name	Description
OTHER	Low glycemic index dietary intervention program	The intervention group involves dietary advice and monitoring. No drug or invasive procedure is involved.
OTHER	simple lifestyle advice	The control group receives lifestyle advice from a clinician, and the clinical care is not inferior to current practice.

Timeline

• Start date: 2009-02-01
• Primary completion: 2012-05-01
• Completion: 2012-05-01
• First posted: 2009-03-25
• Last updated: 2014-02-24

Locations

1 site across 1 country: China