NCT00868712

Warfarin and Coronary Calcification Project

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 70 (actual)
• Sponsor: Walter Reed Army Medical Center · Federal
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to assess whether the use of warfarin, a commonly used anticoagulation drug, is associated with increased amounts of coronary artery calcification. Studies in animals and preliminary but small retrospective studies in humans have suggested a possible link to increased tissue calcification with use of this drug. The researchers will investigate this by assessing the amount of calcification seen in the coronary arteries using a specialized computed tomography (CT) scan (electron-beam CT) and assessing to see if the amount is influenced by the amount of time a patient has been taking warfarin. The researchers will exclude patients with known coronary artery disease, chronic kidney disease or hyperparathyroidism.

Conditions

• Coronary Calcification

Timeline

• Start date: 2004-05-01
• Primary completion: 2010-01-01
• Completion: 2010-01-01
• First posted: 2009-03-25
• Last updated: 2012-08-24
• Results posted: 2012-08-24

Locations

1 site across 1 country: United States