Trials / Unknown
UnknownNCT00868270
Urinary Cytokine Levels as a Prognostic Marker for Kidney Scarring After Pyelonephritis
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 35 (estimated)
- Sponsor
- Hillel Yaffe Medical Center · Other Government
- Sex
- All
- Age
- 7 Years
- Healthy volunteers
- Not accepted
Summary
The prevalence of kidney scarring after UTI is approximately 5-57%. UTIs are caused mainly by bacteria that cause local and systemic immunological reaction that are accompanied by cytokines. These cytokines are a main factor in the inflammatory process. They are produced by leukocytes, macrophages, fibroblasts, endothelial cells and epithelial cells in the kidney tissue. Interleukin 6 and 8 (IL-6 IL-8) were found in high levels in the urine of children and adults who suffer from UTIs. Other studies on animals have found a relationship between inflammatory reaction and scarring in the kidney. We hypothesize that we will find a similar relationship between the level of IL-6, IL-8 in the urine during acute pyelonephritis in children and the probability of kidney scarring.
Conditions
Timeline
- Start date
- 2009-05-01
- First posted
- 2009-03-24
- Last updated
- 2009-03-24
Locations
1 site across 1 country: Israel
Source: ClinicalTrials.gov record NCT00868270. Inclusion in this directory is not an endorsement.