Trials / Completed
CompletedNCT00865501
Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease
- Status
- Completed
- Phase
- Phase 3
- Study type
- Interventional
- Enrollment
- 50 (actual)
- Sponsor
- University of Erlangen-Nürnberg Medical School · Academic / Other
- Sex
- Male
- Age
- 18 Years – 40 Years
- Healthy volunteers
- Not accepted
Summary
The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension. This study aims at evaluating the importance of aldosterone with regard to hypertension induced damage to the heart. In order to do this the investigators will perform a comparative cross-sectional study in hypertensives and normotensives. In addition as interventional part the hypertensives will be treated with a mineralocorticoid-receptor blocker (spironolactone).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | spironolactone | 25mg per oral once daily |
| DRUG | placebo | placebo |
Timeline
- Start date
- 2008-03-01
- Primary completion
- 2009-12-01
- Completion
- 2009-12-01
- First posted
- 2009-03-19
- Last updated
- 2012-07-10
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT00865501. Inclusion in this directory is not an endorsement.