NCT00864682

Preventing Propofol-associated Injection Pain

Propofol Mixed With Lidocaine Versus Lidocaine Pretreatment With Tourniquet for Alleviation of Pain Associated With Propofol Injection

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 156 (actual)
• Sponsor: Benaroya Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Injection of propofol is associated with discomfort in subsets of patients. Local anesthetics have been shown to attenuate this response in some patients. This randomized, double-blind, placebo-controlled trial tests the hypothesis that lidocaine mixed with propofol will be superior to lidocaine administered directly into the vein, under tourniquet control, prior to injection of propofol. Both groups are expected to be superior to placebo.

Conditions

• Pain

Interventions

Type	Name	Description
DRUG	Saline	3.3 mL normal saline
DRUG	Lidocaine / propofol admixture	lidocaine 50 mg plus propofol 50 mg intravenous (iv)
DRUG	lidocaine pretreatment	lidocaine 50 mg iv under tourniquet-control

Timeline

• Start date: 2008-01-01
• Primary completion: 2009-03-01
• Completion: 2009-04-01
• First posted: 2009-03-19
• Last updated: 2021-01-27
• Results posted: 2009-08-03

Locations

1 site across 1 country: United States