NCT00864201

A Study to Evaluate the Use of Bosentan in Patients With Exercise Induced Pulmonary Arterial Hypertension Associated With Connective Tissue Disease

A Pilot Study to Evaluate the Effect of Bosentan in Patients With Exercise Induced Pulmonary Arterial Hypertension Associated With Connective Tissue Disease

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Hamilton Health Sciences Corporation · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary objectives of this exploratory study are to evaluate the effects of bosentan on hemodynamics (via cardiac catheterization) during exercise in patients with Pulmonary Arterial Hypertension (PAH) who have abnormal hemodynamics during exercise but normal hemodynamics at rest. The authors hypothesize that early treatment may change the course of disease progression by improving hemodynamics during exercise, thus delaying disease progression.

Conditions

• Hypertension, Pulmonary
• Connective Tissue Disease

Interventions

Type	Name	Description
DRUG	bosentan	bosentan 62mg bid x 4 weeks, followed by bosentan 125mg bid x 20 weeks

Timeline

• Start date: 2009-04-01
• Primary completion: 2010-04-01
• Completion: 2010-04-01
• First posted: 2009-03-18
• Last updated: 2009-03-18

Locations

1 site across 1 country: Canada