NCT00864188

The Influence of Probiotics in a Drinkable Yogurt on Skin Health

Phase 1 The Influence of Probiotics in a Drinkable Yogurt on Skin Health

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 207 (actual)
• Sponsor: Société des Produits Nestlé (SPN) · Industry
• Sex: Female
• Age: 25 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to test if probiotics administered to healthy female subjects in a dairy format have any skin health benefits.

Detailed description

This is a placebo-controlled, double blind, randomized, single center, human clinical trial aimed at assessing the influence of probiotics on skin health in healthy female subjects, when administered in a food matrix over a period of 5 months. It will consist of five groups(40 subjects/group). The first group (1) of subjects will receive acidified milk that does not contain bacterial strains. The second group (2) will receive acidified milk that contains one specific probiotic strain. The third group (3) will receive fermented milk that contains a standard mix of yogurt bacterial strains. The fourth group (4) will receive fermented milk, containing the same standard mix of yogurt bacterial strains as in group 3 plus the same specific probiotic strain as in group 2. Finally, the fifth group (5) will receive fermented milk, containing the same standard mix of yogurt bacterial strains as in group 3 and 4 plus the same specific probiotic strain as in group 2 and 4 plus a mix of antioxidants. This study will address whether: A.The bioefficacy of a specific probiotic strain is influenced by a milk matrix. B.Whether other bacterial strains impact the bioefficacy of this specific probiotic strain, and validate whether or not the bioefficacy is related entirely to the activity of this specific probiotic strain. C.Whether nutritional supplements impact the bioefficacy of a specific probiotic strain.

Conditions

• Skin Health

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	no bacterial strains	Glucono-Delta-Lactone acidified milk containing no bacterial strains
DIETARY_SUPPLEMENT	One probiotic strain - Lactobacillus paracasei NCC2461	Glucono-Delta-Lactone acidified or fermented milk containing one probiotic strain.
DIETARY_SUPPLEMENT	Two standard yogurt fermenting bacterial strains - Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus	Fermented milk containing two standard yogurt bacterial strains.
DIETARY_SUPPLEMENT	Vit B2, B3, C and E, Beta Carotene and Oil	Fermented milk containing nutritional supplements

Timeline

• Start date: 2009-02-01
• Primary completion: 2010-04-01
• Completion: 2010-04-01
• First posted: 2009-03-18
• Last updated: 2013-05-16

Locations

1 site across 1 country: Germany