NCT00863460

Cranial Radiotherapy or Intensive Chemotherapy With Hematopoietic Stem Cell Rescue for Primary Central Nervous System Lymphoma in Young Patients

Prospective , Multicentric, Randomized Phase II Study, Evaluating the Role of Cranial Radiotherapy or Intensive Chemotherapy With Hematopoietic Stem Cell Rescue After Conventional Chemotherapy for Primary Central Nervous System in Young Patients (< 60 y)

• Status: Active Not Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 140 (actual)
• Sponsor: Institut Curie · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Purpose of the study : To evaluate the antitumoral effect of two therapeutic procedures and to evaluate their respective toxicity on the CNS.

Conditions

• Primary Central Nervous System Lymphoma

Interventions

Type	Name	Description
RADIATION	cranial radiotherapy	40 Gy
DRUG	intensive chemotherapy and hematopoietic stem cell rescue	intensive chemotherapy and hematopoietic stem cell rescue
DRUG	MTX based chemotherapy	R-MBVP 2 cycles day1 and day28 followed by R-Aracytine 2 cycles days58\&59 and days79\&80

Timeline

• Start date: 2008-10-03
• Primary completion: 2016-05-17
• Completion: 2026-05-01
• First posted: 2009-03-18
• Last updated: 2019-02-05

Locations

23 sites across 1 country: France