Trials / Completed
CompletedNCT00861900
Immune Mechanisms of Rejection in Human Lung Allografts
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 778 (actual)
- Sponsor
- Washington University School of Medicine · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Not accepted
Summary
The investigators have obtained compelling evidence that the development of anti-human leukocyte antigen (anti-HLA) antibodies against mismatched donor antigens significantly correlates with the development of bronchiolitis obliterans (BOS). Further, these anti-HLA antibodies are developed at least 15 months prior to any clinical evidence of BOS. This lag period between the development of anti-HLA antibodies and the onset of BOS gives us an opportunity to intervene to delay and/or prevent the development of BOS.
Conditions
Timeline
- Start date
- 1998-01-01
- Primary completion
- 2017-07-01
- Completion
- 2017-07-01
- First posted
- 2009-03-16
- Last updated
- 2018-06-19
Source: ClinicalTrials.gov record NCT00861900. Inclusion in this directory is not an endorsement.