NCT00858767

Arabic Gum-Absorption Study

Comparison of Absorption and Efficacy of 3 Different Menaquinone-7 Delivery Systems; Casein Powder, Arabic Gum Powder, or Linseed Oil

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 69 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Previous studies have indicated that menaquinone-7 (MK-7) is the most effective form of vitamin K. The Japanese soya product natto is one of the richest food sources of MK-7, but its taste is not appreciated by the Western society. For this reason, the active biological compound has been manufactured as enriched oil or casein (≈80% of proteins in cow's milk)-enriched powder. However, cow's milk allergy is the most common cause of food allergy affecting a minimum of 2-3% of infants. The investigators will therefore compare this protein-delivery system to an alternative delivery system (Arabic gum; 98% polysaccharides). To compare the difference between powder and oil as MK-7 delivery vehicle, the investigators will also test the efficacy of enriched linseed oil.

Conditions

• Bioavailability

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	menaquinone-7 from casein capsules	90 µg menaquinone-7 daily during 8 weeks
DIETARY_SUPPLEMENT	menaquinone-7 from arabic gum capsules	90 µg menaquinone-7 daily during 8 weeks
DIETARY_SUPPLEMENT	menaquinone-7 from linseed oil capsules	90 µg menaquinone-7 daily during 8 weeks

Timeline

• Start date: 2008-10-01
• Primary completion: 2009-05-01
• Completion: 2009-08-01
• First posted: 2009-03-10
• Last updated: 2010-12-16

Locations

1 site across 1 country: Netherlands