NCT00857610

Retinol-induced Dermatitis in Aged Skin

Molecular Analyses of Retinoid-induced Dermatitis in Aged/Photoaged Human Skin

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 41 (actual)
• Sponsor: University of Michigan · Academic / Other
• Sex: All
• Age: 21 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Topical therapy with retinoids is the only proven medical therapy for aged/photoaged human skin. However, topical therapy with retinoids often result in unwanted cutaneous dermatitis, including erythema and scaling. The reseachers intend to investigate the dose, frequency of use, and time dependence of topical retinol-induced dermatitis. The researchers intend to evaluate retinoid-induced dermatitis biochemically, including retinol regulation of retinoid responsive genes that control retinoid metabolism and serve as markers for retinoid bioactivity. The researchers will also investigate the role of EGF receptor pathway in retinoid-induced dermatitis.

Conditions

• Aged Skin
• Photoaged Skin

Timeline

• Start date: 2009-07-20
• Primary completion: 2014-08-29
• Completion: 2014-08-29
• First posted: 2009-03-06
• Last updated: 2020-03-13

Locations

1 site across 1 country: United States