NCT00856947

Vitamin D Supplementation During Pregnancy for Prevention of Asthma in Childhood

Vitamin D Supplementation During Pregnancy for Prevention of Asthma in Childhood: An Interventional Trial in the ABC (Asthma Begins in Childhood) Cohort

• Status: Active Not Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Copenhagen Studies on Asthma in Childhood · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to prevent asthma symptoms (recurrent wheeze) in childhood by supplementation with high dose vitamin D to the mother during pregnancy. Participants are mothers and children of the ABC (Asthma Begins in Childhood) cohort. Mothers are recruited during pregnancy and receive daily supplement with 2400 IU of Vitamin D3 or placebo from week 24 og gestation to 1 week after delivery. In addition all mothers are advised to take the recommended dose of 400 IU vitamin D daily. The mothers in ABC also participate in an interventional trial with fish oil supplementation, and the vitamin D randomization is stratified by fish oil treatment group. The child is followed with acute and planned vits at the research unit, and wheeze is diagnosed according to predefined algorithms.

Conditions

• Asthma

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Cholecalciferol D3	2 tablets of 1200 IU daily from week 24 of gestation to 1 week after delivery
OTHER	Placebo tablet	2 tablets containing no active substance

Timeline

• Start date: 2009-03-01
• Primary completion: 2027-07-01
• Completion: 2027-07-01
• First posted: 2009-03-06
• Last updated: 2026-03-19

Locations

2 sites across 1 country: Denmark