NCT00856934

Effect of Platelet Rich Plasma and Keratinocyte Suspensions on Wound Healing

A New Model to Enhance Wound Healing Using Autologous Keratinocytes in Platelet Concentrates - a Prospective Randomized Trial.

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Centre Hospitalier Universitaire Vaudois · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This prospective randomized trial evaluated the impact of autologous keratinocytes suspended in platelet concentrates on healing skin graft donor site wounds. It was hypothesized that the treatment would speed and improve wound healing.

Conditions

• Skin Graft

Interventions

Type	Name	Description
BIOLOGICAL	Autologous Platelet Rich Plasma	Platelet Rich Plasma isolated from patient blood sprayed onto wound bed along with 10% Calcium Chloride solution in a 10 to 1 proportion.
BIOLOGICAL	Keratinocyte suspension	Autologous keratinocytes isolated from skin biopsy suspended in platelet rich plasma before spraying.
OTHER	Standard dressings	Three layers of paraffin gauze, topped with standard dry bandages and an elastic bandage.

Timeline

• Start date: 2005-06-01
• Primary completion: 2006-03-01
• First posted: 2009-03-06
• Last updated: 2009-03-06
• Results posted: 2009-03-06

Locations

1 site across 1 country: Switzerland