Trials / Completed
CompletedNCT00854178
Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 26 (estimated)
- Sponsor
- UPECLIN HC FM Botucatu Unesp · Academic / Other
- Sex
- All
- Age
- 18 Years – 50 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.
Detailed description
It is expected that the results provide relevant information to understand the possible adverse effects of anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed individuals.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Comparison of two anesthetic drugs | Isoflurane 1,0 minimum alveolar concentration Propofol 2mg/kg and 4ug/ml |
Timeline
- Start date
- 2008-03-01
- Primary completion
- 2009-12-01
- Completion
- 2009-12-01
- First posted
- 2009-03-03
- Last updated
- 2010-01-06
Locations
1 site across 1 country: Brazil
Source: ClinicalTrials.gov record NCT00854178. Inclusion in this directory is not an endorsement.