NCT00851149

Pro-inflammatory Cytokines in Blood From Orthopedic Surgery Compared to Abdominal Aneurysm Repair

Pro-inflammatory Cytokines (IL-1beta,IL-6, IL-8 and TNF-α) and Complement Activation (C3a) in Blood Collected From Surgery Field From Patients Undergoing Orthopedic Surgery Compared to Patients Undergoing Abdominal Aneurysm Repair.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Sykehuset i Vestfold HF · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery. Is there any difference in pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-α), complement activation (C3a)?

Detailed description

Patient (n= 10) scheduled for total hip replacement or hemiprosthesis and patient (n=10) scheduled for abdominal aortic surgery. Primary outcome: Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups. Secondary outcome: Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups.

Conditions

• Aortic Diseases
• Osteoarthritis, Hip

Interventions

Type	Name	Description
DEVICE	Sangvia blood sampling system	Blood collected from abdominal aortic repair patients are compared against blood collected from total hip replacement patients

Timeline

• Start date: 2009-11-01
• Primary completion: 2010-02-01
• Completion: 2010-05-01
• First posted: 2009-02-25
• Last updated: 2010-06-11

Locations

1 site across 1 country: Norway