NCT00849264

Comprehensive Treatment for Different Types of Tumor Thrombi in the Portal Vein for Hepatocellular Carcinoma Patients

a Randomized Controlled Study of Surgical Comprehensive Treatment for Different Types of Tumor Thrombi in the Portal Vein for Hepatocellular Carcinoma Patients

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Eastern Hepatobiliary Surgery Hospital · Academic / Other
• Sex: All
• Age: 30 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study is working to evaluate the surgical comprehensive treatment for different types of tumor thrombi in the portal vein for hepatocellular carcinoma patients, to establish a standardized, unified, effective therapeutic program.

Detailed description

Primary liver cancer (PLC) has a great tendency to invade portal vein intravascularly, results in the formation of portal vein tumor thrombus (PVTT), which is a crucial factor that can worsen the prognosis of patients with PLC. In clinical, various treatments have been applied to improve this short-term prognosis, but there was no identical indication for treatment of PLC patients with different PVTT. The objective of this study is to evaluate the surgical comprehensive treatment for different types of tumor thrombi in the portal vein for hepatocellular carcinoma patients, to establish a standardized, unified, effective therapeutic program.

Conditions

• Hepatocellular Carcinoma
• Portal Vein Tumor Thrombus

Interventions

Type	Name	Description
DRUG	chemotherapy with endostar	15mg/d×14d
DRUG	treatment with CBP and 5-FU	CBP 300mg/d×2d，5-FU 1000mg/d×5d
DRUG	treatment with endostar, CBP and 5-FU	CBP 300mg/d×2d，5-FU 1000mg/d×5d ，Endostar 15mg/d×14d

Timeline

• Start date: 2008-12-01
• Primary completion: 2009-12-01
• Completion: 2010-12-01
• First posted: 2009-02-23
• Last updated: 2016-04-01

Locations

1 site across 1 country: China