Trials / Suspended
SuspendedNCT00846378
Minimizing Reperfusion Injury in Patients With Acute Myocardial Infarction
The Mechanism of Ischemic Post-conditioning in Humans: Minimizing Reperfusion Injury in Patients With Acute Myocardial Infarction
- Status
- Suspended
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- Sponsor
- University of Cincinnati · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The size of a heart attack will be decreased by the use of timed balloon inflations to open the blocked blood vessel.
Detailed description
The intervention of "post conditioning" at the time of reperfusion, in patients with acute myocardial infarction (AMI), will attenuate the degree of ischemia-reperfusion injury, as manifested by infarct size. This intervention is hypothesized to be safe in humans.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Post conditioning | after 30 seconds of re-established coronary flow following the therapeutic balloon dilatation and deflation, the same balloon will be re-inflated for 30 seconds and then again deflated for 30 seconds. This procedure of balloon inflation/deflation will be performed a total of 3 to 4 times. |
| PROCEDURE | Usual Care for STEMI | Usual care for treatment of TIMI 0 to TIMI 1 flow in occluded infarct related artery. Usual care includes reperfusion of the artery per operator discretion, i.e. primary stenting, thrombectomy, balloon inflation/deflation without timed intervals. |
Timeline
- Start date
- 2008-03-01
- Primary completion
- 2010-05-01
- First posted
- 2009-02-18
- Last updated
- 2014-02-03
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00846378. Inclusion in this directory is not an endorsement.