NCT00846235

Effect of Moisturising Creams on Skin Moisture in Atopic Dermatitis

Clinical Evaluation of the Effect of Moisturising Cream on Skin Moisture in Atopic Dermatitis

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Orion Corporation, Orion Pharma · Industry
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is evaluate the effect of three moisturising creams on Stratum corneum (SC) hydratation and barrier function.

Detailed description

In the present study, 24 subjects with AD will be treated for 3 weeks twice daily by using 3 different moisturising creams. Duration of the study is based on literature. Various moisturising creams containing glycerol have been reported to be beneficial for AD lesions. The optimal glycerol content in moisturising creams is not known. The secondary objective is the comparison of change in the SC water content and in the TEWL from the skin surface from the baseline to the end of study between different moisturizing creams containing different amount of glycerol. Change in the SC water content and in the TEWL can be demonstrated with noninvasive instrumental measurement. The treated skin will be followed up instrumentally, and one measurement area will serve as an untreated control. The primary evaluation is the comparison of change in the SC water content and in the TEWL on the skin surface from the baseline to the end of study between the 4 treatments.

Conditions

• Dermatitis, Atopic

Interventions

Type	Name	Description
OTHER	Aqualan L, Aqualan Plus, Aqualan L + glycerol ad 20%	moisturising cream twice daily three weeks

Timeline

• Start date: 2008-12-01
• Primary completion: 2009-03-01
• Completion: 2009-05-01
• First posted: 2009-02-18
• Last updated: 2009-10-08

Locations

1 site across 1 country: Finland