NCT00845689

Prevention of Liver Damage During Liver Surgery

Study on the Potential Role of Intraoperative Hepatoprotection During Liver Resections

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: —
• Sponsor: Ludwig-Maximilians - University of Munich · Academic / Other
• Sex: —
• Age: —
• Healthy volunteers: —

Summary

Liver damage as a consequnce of ischemia (I) and reperfusion (R) is known to harm the liver and could hence be a critical factor of the postoperative outcome of patients undergoing liver surgery. In order to protect the liver from ischemic damage following interventions such as the Pringle Maneuver, preconditioning has been successfully applied in various animal models as well as in humans. Since ischemia inevitably leads to cell hypoxia and subsequnet release of endogenuous metabolites, the investigators hypothesize that instead of brief periods of ischemia, the exogenuous infusion of purine analogues may also protect against subsequent prolonged periods of ischemia. Moreover, after reperfusion, the antiinflamamtory action of purine ananlogue infusion can further attenuated liver damage.

Conditions

• Liver Tumors

Interventions

Type	Name	Description
DRUG	placebo	NaCl 0,9 %
DRUG	adenosine	intravenous infusion of adenosine 0, 2 %
DRUG	adenosine	intravenous infusion of adenosine 0,2 %
PROCEDURE	Liver resection	Liver resection with Pringle maneuver

Timeline

• First posted: 2009-02-18
• Last updated: 2009-02-18