NCT00845013

Epidemiology and Pathogenesis of HIV-Associated Pulmonary Hypertension

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 365 (actual)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to describe the epidemiology of pulmonary hypertension in individuals with HIV infection and to investigate its pathogenesis. We propose to conduct a prospective observational cohort study to determine the association between highly active antiretroviral therapy (HAART) and viral suppression in HIV-infected patients who have been identified to have pre-clinical pulmonary hypertension (Aim 1). In addition, we will investigate the mechanistic role of the HIV-1 Nef protein and HHV-8 infection in the development and progression of pulmonary hypertension in individuals with HIV (Aim 2). We will also investigate endothelial function in HIV-infected patients with pulmonary hypertension (Aim 3).

Conditions

• HIV Infection
• Pulmonary Hypertension
• Endothelial Function
• HIV Infections

Timeline

• Start date: 2007-11-01
• Primary completion: 2021-01-01
• Completion: 2021-01-01
• First posted: 2009-02-16
• Last updated: 2021-11-10

Locations

1 site across 1 country: United States