NCT00844363

Narrowband UVB Phototherapy in the Treatment of Psoriasis Vulgaris

Mechanism of Action of Narrowband UVB Phototherapy in the Treatment of Psoriasis Vulgaris

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Rockefeller University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Ultra-violet light B (UVB) therapy has been used by dermatologists to treat psoriasis for decades. Only a few studies have begun to dissect the mechanism of how NB-UVB therapy causes lesion resolution. Results from this study will aid in identifying other diseases that may be treated successfully with NB-UVB. If we can identify the mechanism of action of this therapy, this may give us additional new therapeutic targets for psoriasis and other diseases. Our overall hypothesis is that UVB induces changes that will indicate a mechanism of action of this therapy in psoriasis.

Conditions

• Chronic Plaque Psoriasis

Interventions

Type	Name	Description
PROCEDURE	NB-UVB	UVB light will be administered to the entire body except for the genitals in men and eyelids, which will be shielded.NB-UVB dosing is increased by 5-20% increments in exposure time, depending on response of the patient.

Timeline

• Start date: 2008-11-01
• Primary completion: 2011-05-01
• Completion: 2011-05-01
• First posted: 2009-02-16
• Last updated: 2011-06-30

Locations

1 site across 1 country: United States