NCT00843453

Long-term Use of Proton Pump Inhibitors May Cause Vitamin B12 Deficiency in the Institutionalized Elderly

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: University of Delaware · Academic / Other
• Sex: All
• Age: 60 Years – 89 Years
• Healthy volunteers: Accepted

Summary

This study was designed to determine whether elderly residents of long term care facilitated who had been taking proton pump inhibitors (PPI) for more than 12 months were more likely to have vitamin B12 deficiency than residents not taking PPI, and whether cyanocobalamin nasal spray improved these subjects' vitamin B12 status.

Detailed description

Subjects had serum creatinine \<1.8 mg/dL, no diagnosis of severe megaloblastic or pernicious anemia, and had not been taking vitamin B12 supplements. At baseline, serum vitamin B12 and methylmalonic acid (MMA) concentrations of 34 subjects from the PPI group were compared with those of the non-PPI group. The PPI group (n=13) was treated with cyanocobalamin nasal spray for eight weeks, and post-treatment vitamin B12 and MMA concentrations were compared with baseline concentrations.

Conditions

• Vitamin B12 Deficiency

Interventions

Type	Name	Description
OTHER	blood collection	blood collection
DRUG	treatment (cyanocobalamin nasal spray)	cyanocobalamin nasal spray -- 500 mcg q week for eight weeks

Timeline

• Start date: 2006-11-01
• Primary completion: 2008-01-01
• Completion: 2008-04-01
• First posted: 2009-02-13
• Last updated: 2009-07-23

Locations

2 sites across 1 country: United States