NCT00841945

Treatment of Aggressive Localized Lymphoma

Phase III Study of the Interest of Radiotherapy After 4 or 6 Cycles of CHOP 14 Rituximab Regimen of Chemotherapy , Patients With Agressive Localized Lymphoma

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 334 (actual)
• Sponsor: French Innovative Leukemia Organisation · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Prospective and multicentric Phase III study, evaluation of the interest of the radiotherapy after 4 or 6 cycles of CHOP 14 R regimen of chemotherapy , patients with agressive and localized B lymphoma , age 18 to 75 years.

Detailed description

CHOP 14 R regimen of chemotherapy is a good standard in the treatment of agressive and localized B lymphoma. Interest of the radiotheraphy

Conditions

• B Cell Lymphoma

Interventions

Type	Name	Description
DRUG	rituximab	RITUXIMAB 375 MG/M² IV DAY 1 or each course
DRUG	doxorubicin	doxorubicin 50 mg / m² iv day 1 of each course
DRUG	vincristine	VINCRISTINE 1?4 MG/M² IV ON DAY 1
DRUG	prednisone	Prednisone 40 mg/m² DAy 1 to day 5
PROCEDURE	radiotherapy	radiotherapy : total dose = 40 GY (5 fractions by week)

Timeline

• Start date: 2005-04-01
• Primary completion: 2016-01-01
• Completion: 2017-02-01
• First posted: 2009-02-12
• Last updated: 2017-02-23

Locations

1 site across 1 country: France