NCT00838305

Role of Serotonin in Acute and Subacute MDMA Effects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: California Pacific Medical Center Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to measure the effects of MDMA (particularly its emotional effects) and to determine the role of serotonin in these effects. Serotonin is a neurotransmitter, which is a chemical that is released by some brain cells to communicate with other brain cells. Many of the effects of MDMA are thought to be the result of increased serotonin release. In order to understand the effects of MDMA and role of serotonin in these effects, we will administer MDMA alone and in combination with the antidepressant citalopram (one trade name for this is Celexa). Citalopram decreases the ability of MDMA to release serotonin. Citalopram will therefore decrease any of MDMA's effects that are the result of serotonin release; we want to measure this.

Conditions

• MDMA Mechanism of Action

Interventions

Type	Name	Description
DRUG	MDMA and citalopram	MDMA 1.5 mg/kg and citalopram 20 mg
DRUG	Placebo	drug: placebo subjects also get citalopram and placebo in a 2x2 crossover design

Timeline

• Start date: 2009-02-01
• Primary completion: 2009-12-01
• Completion: 2011-08-01
• First posted: 2009-02-06
• Last updated: 2013-05-31

Locations

1 site across 1 country: United States