NCT00837733

Endometrial Local Injury and Implantation Failure

Endometrial Local Injury Improves the Pregnancy Rate Among Recurrent Implantation Failure Patients Undergoing IVF/ICSI

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 115 (actual)
• Sponsor: Yazd Research & Clinical Center for Infertility · Academic / Other
• Sex: Female
• Age: 15 Years – 39 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to evaluate the influence of endometrial biopsy on increasing implantation rate in patients with recurrent implantation failures, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group. The results suggest that in vitro fertilization or intracytoplasmic sperm injection after endometrial biopsy increase pregnancy outcome.

Detailed description

In a randomized control trial study, 93 women with at least two implantation failures were evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal phase of previous cycle and implantation and clinical pregnancy rate were compared with 45 patients in control group. The implantation rate was determined as 10.9% in biopsy group compared with 3.38% in controls. Clinical pregnancy rate was significantly higher in case group than controls (27.1% and 8.9% respectively

Conditions

• Infertility

Interventions

Type	Name	Description
PROCEDURE	Endometrial biopsy	Endometrial biopsy was done at luteal phase on the day 21-26 of spontaneous menstrual cycles, when GnRH agonist uses begun. Endometrial samples were taken by a biopsy catheter
PROCEDURE	Endometrial Biopsy	Biopsy catheter

Timeline

• Start date: 2008-01-01
• Primary completion: 2008-11-01
• Completion: 2008-12-01
• First posted: 2009-02-05
• Last updated: 2009-02-05

Locations

1 site across 1 country: Iran