NCT00836862

Arteriovenous Fistula Tissue Bank for Pre- and Post-Fistula Placement Specimens

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 43 (actual)
• Sponsor: University of Nebraska · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

This project will bank sera, DNA and vascular specimens from patients undergoing arteriovenous fistula creation and revision.

Detailed description

Hemodialysis patients utilizing an arteriovenous fistula (AVF) for hemodialysis access are 10 times less likely to develop bacteremia than those patients utilizing a hemodialysis catheter. Because of this, a great focus has been on placing AVF in all patients undergoing hemodialysis. While AVF are relatively simple to place from a surgical standpoint, 30-60% of AVF will not mature adequately to be used for hemodialysis. In order to be utilized for hemodialysis, the blood flow in the vein used to create the AVF will need to increase by over 100 fold. In order to do so, the vein will need to dilate by more than 150%. AVF which fail to mature do not dilate, and the major histologic finding in these AVF has been neointimal hyperplasia. The factors (both circulating and tissue) which contribute to AVF maturation or failure are poorly understood, and investigations in this area are limited. Current studies in the literature have either described pre-AVF vein characteristics, or have looked at serum or tissue specimens following AVF failure. To date, no studies have looked at specimens from patients both before and after fistula placement, or described factors associated with fistula maturation. This project will bank sera, DNA and vascular specimens from patients undergoing arteriovenous fistula creation and revision.

Conditions

• Kidney Failure, Chronic

Interventions

Type	Name	Description
OTHER	Biologic specimens	Banking of serum, DNA and tissue

Timeline

• Start date: 2009-02-01
• Primary completion: 2012-11-10
• Completion: 2017-09-07
• First posted: 2009-02-04
• Last updated: 2023-12-28

Locations

1 site across 1 country: United States