NCT00827450

Effects of Coffee on Hepatic Steatosis Induced by a High Fructose Diet

Effects of Coffees With Various Compositions of Antioxidants on Hepatic Steatosis Induced by a High Fructose, Hypercaloric Diet

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: University of Lausanne · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This study will assess * whether coffee consumption protects against fructose-induced hepatic steatosis in healthy humans * whether the protective effect of coffee is dependent on it's antioxidant composition

Detailed description

Epidemiological studies suggest that coffee consumption improves glucose homeostasis in insulin resistant subjects. An increase in intrahepatic lipids (hepatic steatosis) is highly prevalent in patients with the metabolic syndrome and may be used as a marker of altered hepatic lipid metabolism. Such an increased hepatic lipids content can be experimentally produced in healthy humans by a 6-day high fructose diet. The purpose of this study is to evaluate whether coffee prevents hepatic lipid deposition in healthy male subjects fed a fructose-rich hypercaloric diet. Both caffeine and antioxidants (yet unspecified) may be involved.. To sort out the role of caffeine and antioxidants, we will test 3 different soluble coffee, ie fully torrefied decaffeinated coffee , partially torrefied decaffeinated coffee, and partially torrefied caffeinated coffee.

Conditions

• Hepatic Steatosis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ctl	Control, isocaloric diet; no coffee
DIETARY_SUPPLEMENT	High fructose diet; no coffee	Hypercaloric, high fructose diet; no coffee
DIETARY_SUPPLEMENT	fully torrefied, caffeine-free coffee	Hypercaloric, high fructose diet + coffee
DIETARY_SUPPLEMENT	partially torrefied, caffeine-free coffee	Hypercaloric, high fructose diet + coffee
DIETARY_SUPPLEMENT	Partially torrefied, caffeinated coffee	Hypercaloric, high fructose diet + coffee

Timeline

• Start date: 2009-02-01
• Primary completion: 2010-12-01
• Completion: 2011-03-01
• First posted: 2009-01-22
• Last updated: 2012-02-24

Locations

1 site across 1 country: Switzerland