NCT00826943

Is Levocetirizine Less Sedating Than Cetirizine?

Is Levocetirizine Less Sedating Than Cetirizine? A Randomized, Double-blind, Placebo Controlled Trial.

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: 18 Years – 77 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether cetirizine (zyrtec), levocetirizine (xyzal), and placebo differ in the degree of sedation they produce and their relief of allergy symptoms.

Detailed description

Levocetirizine, the R-enantiomer of cetirizine, has been found to be less sedating relative to placebo than was cetirizine in separate trials. We plan to examine whether patients who did not tolerate cetirizine due to sedation are able to tolerate levocetirizine. This study will utilize a randomized, double-blind, placebo controlled trial comparing levocetirizine, cetirizine, and placebo in regards to sedation and allergy symptom scores. Each patient will receive levocetirizine, cetirizine, and placebo in randomized order and thus serve as their own control.

Conditions

• Allergic Rhinitis

Interventions

Type	Name	Description
DRUG	Cetirizine	Cetirizine 10 mg tab daily x 7 days
DRUG	Levocetirizine	5 mg tab daily x 7 days
DRUG	Placebo	Placebo tablet daily x 7 days

Timeline

• Start date: 2009-01-01
• Primary completion: 2009-05-01
• Completion: 2009-05-01
• First posted: 2009-01-22
• Last updated: 2014-02-20
• Results posted: 2014-02-20

Locations

1 site across 1 country: United States