NCT00825851

Effect of Smoking, Abstention and Nicotine Replacement Therapy on Wound Healing

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: Bispebjerg Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The aim was to determine the wound healing capacity in healthy never smokers and smokers who continue to smoke, or quit smoking using transdermal nicotine patch versus placebo patch.

Detailed description

Two wound healing models were applied: the excisional skin biopsy model to study wound histology and the suction blister model to study epidermal regeneration and skin transudate. In addition blood sampling was made to validate compliance to the study arms and to study systemic markers of collagen metabolism and oxidative stress. In addition, wound infections and wound ruptures were recorded post hoc as complications to the excisional skin biopsy model were not expected to occur.

Conditions

• Wound Healing

Interventions

Type	Name	Description
DRUG	Transdermal nicotine patch	15mg/16h + 10mg/16h to be used 24h
DRUG	Placebo patch
BEHAVIORAL	Smoking cessation
BEHAVIORAL	Continuous smoking	subjects smoke 20 cigarettes per day

Timeline

• Start date: 2000-08-01
• Primary completion: 2000-12-01
• Completion: 2001-01-01
• First posted: 2009-01-21
• Last updated: 2009-01-21

Locations

1 site across 1 country: Denmark