NCT00824889

Exploratory Study of Natural Killer Cells in Human Skin

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 28 (actual)
• Sponsor: Assistance Publique Hopitaux De Marseille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Natural Killer (NK) cells play a unique role during innate immune responses as they are able to recognize and eliminate, without specific sensitization, tumors, microbe-infected cells as well as allogeneic cells.In a first time, we will characterize the tissue distribution, the phenotype and the effector functions of NK cells present in the human healthy skin.

Detailed description

Then, we will define whether these parameters are qualitatively/ quantitatively modified in the following skin pathologies: a) atopic dermatitis; b) contact dermatitis; c) psoriasis ; d) lichen planus ; e) GVH (graft versus host disease) ; (f) melanoma.

Conditions

• Atopic Dermatitis
• Contact Dermatitis
• Psoriasis
• Lichen Planus
• Graft Versus Host Disease
• Melanoma

Interventions

Type	Name	Description
OTHER	Biopsy and sample of blood	Biopsy and sample of blood
OTHER	Biopsy and sample of blood	Biopsy and sample of blood
OTHER	Biopsy and sample of blood	Biopsy and sample of blood
OTHER	Biopsy and sample of blood	Biopsy and sample of blood
OTHER	Biopsy and sample of blood	Biopsy and sample of blood
OTHER	Biopsy and sample of blood	Biopsy and sample of blood
OTHER	Biopsy and sample of blood	Biopsy and sample of blood

Timeline

• Start date: 2009-02-01
• Primary completion: 2011-11-01
• Completion: 2011-11-01
• First posted: 2009-01-19
• Last updated: 2014-08-29

Locations

1 site across 1 country: France