NCT00824551

The Effects of Hyperbaric Oxygen Therapy (HBOT) on Acute Thermal Burns

The Effects of Hyperbaric Oxygen Therapy on Acute Thermal Burns

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Singapore General Hospital · Academic / Other
• Sex: All
• Age: 21 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The blinded RCTstudy aims to: * Determine the effects of HBOT on burns conversion for patients who have fresh thermal burns injury using the LDI. * Objectively determine the proportion of burns conversion in areas of partial thickness burns for early thermal burns injury in both arms of the RCT. * Study the effects of HBOT on immunological markers IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α and TGF-β ( comparison between both arms and 2 assessment points). * Study the effect of HBOT on haematological markers including procalcitonin ,albumin, lymphocyte counts, neutrophil count, and macrophage count. * Study the effects of HBOT on histology specimens in quantifying P53 protein, leukocyte and macrophage infiltration, burns depth assessment and vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) . * Study the effects of HBOT on bacteriology of tissue culture in areas of deep dermal burns.

Conditions

• Acute Thermal Burns

Interventions

Type	Name	Description
PROCEDURE	Hyperbaric Oxygen Therapy	2 sessions of HBOT ( HDMC 14)
OTHER	Standard care	Patient will undergo standard care

Timeline

• Start date: 2009-01-01
• Primary completion: 2010-12-01
• First posted: 2009-01-16
• Last updated: 2009-01-16

Locations

1 site across 1 country: Singapore