NCT00823628

Contrast-medium Induced Nephrotoxicity in Patients Undergoing Coronary Angiography - Iodixanol Versus Iopromide

Comparison of Contrast-medium Induced Nephrotoxicity Between Iodixanol and Iopromide in Patients With Renal Insufficiency Undergoing Coronary Angiography

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 420 (estimated)
• Sponsor: Seoul National University Bundang Hospital · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

In the treatment of coronary heart disease which is the major cause of heart attack, direct mechanical treatment with catheters such as the coronary angiography, coronary balloon intervention and stenting intervention are the mainstay of therapy in recent years. In that procedures, the investigators should use the contrast media, and it may cause kidney toxicity especially in the patients with underlying kidney disease and decreased kidney function. The investigators intended to find out which contrast agent has less kidney toxicity in the catheter based treatment of coronary arterial diseases in patients with underlying decreased kidney function

Detailed description

Iodixanol, a nonionic, dimeric, iso-osmolar contrast medium (IOCM), may be less nephrotoxic than nonionic, monomeric, low-osmolar contrast media (LOCMs) in high-risk patients. We compared the nephrotoxicity of iodixanol with that of iopromide, an nonionic, monomeric LOCM, in patients with renal impairment.

Conditions

• Chronic Renal Insufficiency
• Coronary Angiography

Interventions

Type	Name	Description
DRUG	contrast agent (iopromide)	coronary angiography using the allocated contrast agent
DRUG	contrast agent (iodixanol)	coronary angiography using the allocated contrast agent

Timeline

• Start date: 2009-02-01
• Primary completion: 2010-05-01
• Completion: 2010-06-01
• First posted: 2009-01-15
• Last updated: 2010-07-07

Locations

1 site across 1 country: South Korea