NCT00823602

Agonist Gonadotropin-Releasing Hormone (GnRH) Versus Antagonist GnRH

Comparison Between GnRH Agonist Long Protocol And GnRH Antagonist Protocol In Outcome Of The First Cycle ART

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 2 (estimated)
• Sponsor: Yazd Research & Clinical Center for Infertility · Academic / Other
• Sex: Female
• Age: 35 Years
• Healthy volunteers: Accepted

Summary

Literature suggests that GnRH antagonists are comparatively more often used in cycles which have an unfavorable prior prognosis, and this protocol is an ideal one for poor responder patients. Up to now, however not enough prospectives have been published to prove any beneficial effect of antagonists on the first cycle assisted reproductive technique. This prospective study will do to evaluate the efficacy of gonadotropin releasing hormone antagonist in comparison with the standard long protocol in the first cycle of ART. The investigators will randomize 160 patients undergoing ART for the first time . Group 1 (n=80) was stimulate with a standard long protocol and group 2 (n=80) stimulated with GnRH antagonist and then result of ART compare in two group .

Conditions

• Infertility

Interventions

Type	Name	Description
DRUG	ganirelix	These patients started ovarian stimulation with 150 - 225 IU Gonal F on the second day of menstrual cycle with an S.C. injection once a day. Initiation of 0.25 mg Ganirelix took place on the 6th of the stimulation (fixed protocol) when HMG (Menogon, ferring, pharmacenticals , Germany ).
DRUG	suprefact	GnRH agonist, standard protocol

Timeline

• Start date: 2008-03-01
• Primary completion: 2008-10-01
• Completion: 2009-01-01
• First posted: 2009-01-15
• Last updated: 2009-01-15

Locations

1 site across 1 country: Iran