NCT00821522

The Influence of Remote Ischemic Preconditioning on Acute Kidney Injury After Cardiac Surgery

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Robert Kramer, MD · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Acute kidney injury is associated with cardiopulmonary bypass during heart surgery and its pathogenesis is similar to that of ischemia-reperfusion injury. Remote ischemic preconditioning attenuates myocardial ischemia-reperfusion injury in patients undergoing coronary bypass surgery. The investigators hypothesize that such preconditioning reduces the incidence of acute kidney injury associated with cardiopulmonary bypass.

Conditions

• Acute Kidney Insufficiency
• Acute Renal Insufficiency
• Acute Kidney Injury
• Ischemic Preconditioning

Interventions

Type	Name	Description
PROCEDURE	Remote Ischemic Preconditioning	Three 5-minute intervals of leg ischemia induced by tourniquet inflation, prior to initiation of cardiopulmonary bypass.

Timeline

• Start date: 2008-11-01
• Primary completion: 2010-03-01
• Completion: 2010-05-01
• First posted: 2009-01-13
• Last updated: 2021-11-17

Locations

1 site across 1 country: United States