NCT00816244

Study of Statin as Neo-Adjuvant Therapy in Postmenopausal Breast Cancer

A Phase II Study of Neo-Adjuvant Statin Therapy in Postmenopausal Primary Breast Cancer: A Window-of-Opportunity Study

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Lund University Hospital · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to monitor: * Tumor biological alterations following two weeks of neo-adjuvant statin therapy. * Effects of statins on tumor proliferation. * Functional studies on the mevalonate pathway.

Detailed description

Blood samples and three core biopsies are taken after diagnosis. Treatment with atorvastatin at a daily dosis of 80 mg is initiated 14 days before planned surgery. Translational research will be performed from the core biopsy and blood samples taken before surgery and from the specimen from surgery.

Conditions

• Breast Cancer
• Postmenopausal

Interventions

Type	Name	Description
DRUG	Atorvastatin	Atorvastatin 80 mg daily for two weeks, ending at the day of operation for breast cancer.

Timeline

• Start date: 2009-01-01
• Primary completion: 2012-03-01
• Completion: 2012-03-01
• First posted: 2009-01-01
• Last updated: 2012-04-13

Locations

1 site across 1 country: Sweden