NCT00812253

Intensive Glycemic Control for Congestive Heart Failure Exacerbation

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 74 (actual)
• Sponsor: Kathleen Dungan · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Patients with heart failure often have high blood sugar (glucose).

Detailed description

Patients with heart failure often have high blood sugar. High glucose contributes to severe hospital complications and even death. Studies suggest that heart failure patients who have high glucose or diabetes do not live as long as patients with normal glucose. In this study, we will determine whether normalizing blood sugars using intravenous insulin short-term will improve outcomes in patients hospitalized for congestive heart failure. We enrolled patients with severe heart failure and randomly assigned them into 2 groups. We used intravenous (given through the vein) insulin to lower blood sugar levels in group 1, and insulin injections in group 2. We determined whether intravenous insulin improved hospital length of stay, rates of readmission, inflammatory markers, and cardiovascular tests that predict mortality in patients with heart failure.

Conditions

• Congestive Heart Failure
• Diabetes Mellitus

Interventions

Type	Name	Description
DRUG	Intravenous insulin	Half of subjects will receive insulin through the intravenous route while the other half will receive 4 injections per day.
DRUG	Subcutaneous insulin	Half of subjects will receive insulin through the intravenous route while the other half will receive 4 injections per day.

Timeline

• Start date: 2009-01-01
• Primary completion: 2013-09-01
• Completion: 2014-05-01
• First posted: 2008-12-22
• Last updated: 2018-01-02
• Results posted: 2014-08-07

Locations

1 site across 1 country: United States