NCT00811330

Effects of High Dose Atorvastatin in Patients With Surgical Aortic Stenosis

Interest of Statin in Surgical Aortic Stenosis: From Myocardial Preconditioning to Ventricular Reverse Remodeling.

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 70 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to see if statin therapy will optimize myocardial response to cardiopulmonary bypass during aortic valve replacement (AVR) for aortic valve stenosis (AVS) (Phase I) and optimize left ventricular reverse remodeling following AVR (Phase II). Preliminary evidence indicates that perioperative statin therapy reduce mortality and morbidity following cardiac surgery. Pleiotropic effects of statins may induce myocardial preconditioning and optimize myocardial and systemic responses to cardiopulmonary bypass during AVR. Furthermore statin therapy after AVR may contribute to an optimal left ventricular reverse remodeling.

Conditions

• Aortic Valve Stenosis
• Ventricular Hypertrophy

Interventions

Type	Name	Description
DRUG	Atorvastatin 80 mg	Atorvastatin 80 mg PO every day for one year. The treatment will start 4 weeks before aortic valve replacement.

Timeline

• Start date: 2008-12-01
• Primary completion: 2018-01-01
• Completion: 2018-01-01
• First posted: 2008-12-19
• Last updated: 2015-06-19

Locations

1 site across 1 country: France