NCT00808912

Does Sildenafil Increase Exercise Performance in Air Pollution?

Decreased Pulmonary Artery Pressure by Oral Sildenafil Injection During Exercise in Air Pollution Increases Exercise Performance.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Marywood University · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to examine if the ingestion of a standard dose of sildenafil enhances the athletic performance of competitive athletes when exercising in a high pollutant environment verses a low air pollutant environment.

Detailed description

This study will evaluate effects of sildenafil on exercise performance while breathing high levels of emission exhaust ultrafine and fine particulate matter. Exercise performance will be measured by work accumulation (total kJ) during a 6-min maximal effort cycle ergometer ride (CER) done immediately after 30 min cycling at 75% of 6 min mean watts determined from familiarization trial. Peak oxygen consumption, cardiac output, pulmonary artery pressure, diffusion capacity(DLco), and SaO2 will be determined for each trial. Blood and urine will be analyzed for sildenafil using LC/MS.

Conditions

• Pulmonary Hypertension
• Pulmonary Artery Pressure
• Exercise Performance
• Air Pollution

Interventions

Type	Name	Description
DRUG	sildenafil	sildenafil 50 mg ingested orally 1 hour prior to exercise testing
OTHER	placebo	matching placebo for sildenafil 50 mg to be ingested orally 1 hour prior to exercise testing.

Timeline

• Start date: 2008-12-01
• Primary completion: 2010-02-01
• Completion: 2010-02-01
• First posted: 2008-12-16
• Last updated: 2010-06-23

Locations

1 site across 1 country: United States