NCT00808717

Efficacy of High Dose atorvaSTATIN Loading Before Primary Percutaneous Coronary Intervention in ST Elevation Myocardial Infarction (STATIN STEMI)

Efficacy of High Dose Atorvastatin Loading in ST Elevation Myocardial Infarction

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 170 (estimated)
• Sponsor: Yonsei University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Although statin prior to PCI has favorable effects in stable angina and ACS except ST elevation MI (STEMI), there have been few studies for STEMI. Celik T et al. reported in patients with STEMI that prior statin use may improve coronary blood flow after PCI in patients with AMI, possibly by its beneficial effects on microvascular function. But this study was retrospective, non-randomized study and evaluated the effects for chronic statin therapy not acute high dose effect. Therefore, the investigators investigated whether acute high-dose statin prior to primary PCI in ST segment elevation myocardial infarction can have beneficial effect or not for periprocedural period and 30 days-cardiac events.

Conditions

• Myocardial Infarction
• Angioplasty
• Percutaneous Coronary

Interventions

Type	Name	Description
DRUG	Atorvastatin	Atorvastatin 10 mg vs. 80 mg before intervention

Timeline

• Start date: 2007-07-01
• Primary completion: 2008-12-01
• First posted: 2008-12-16
• Last updated: 2009-07-15

Locations

1 site across 1 country: South Korea