NCT00804713

Screening for Latent Tuberculosis Infection (LTBI) in US Army Recruits

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 2,017 (actual)
• Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The overall objective of this study is to assess the feasibility and potential impact of using a targeted testing approach and 2 interferon-gamma release assays (IGRA) to screen for latent tuberculosis (TB) infection (LTBI) among military recruits. The current policy of universal application of the Mantoux tuberculin skin test (TST) to screen for LTBI may result in many TST reactions among recruits who are at low risk for LTBI. The central hypothesis is that targeted testing by use of the questionnaire will reduce unnecessary testing of low-risk recruits without affecting the identification of higher-risk recruits. The secondary hypothesis is that many discordant results between the TST and IGRA may be explained by cross-reactivity to non-tuberculous mycobacteria (NTM) with the TST.

Conditions

• Latent Tuberculosis Infection

Interventions

Type	Name	Description
DRUG	BST	0.1 mcg/mL (1 dose) Battey skin test (BST) antigen administered using the Mantoux method.
DRUG	TST	Administer TB Skin test (TST)
OTHER	QFT	Perform QFT TB test
OTHER	T-spot	Perform T-Spot TB test

Timeline

• Start date: 2009-03-01
• Primary completion: 2009-06-01
• Completion: 2022-08-01
• First posted: 2008-12-09
• Last updated: 2023-03-29
• Results posted: 2014-10-15

Locations

1 site across 1 country: United States