NCT00801671

Russian Study of the Effect of Continuous Positive Airway Pressure (CPAP) in Hypertension

Study of Independent Role of Continuous Positive Airway Pressure Therapy on Systemic Arterial Pressure in Patients With Sleep Apnea Syndrome and Arterial Hypertension

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Russian Cardiology Research and Production Center · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether CPAP is effective in the treatment of systemic hypertension.

Detailed description

It is now well known that cardiovascular risks are increased in patients with obstructive sleep apnea syndrome (OSAS). Also a link has already been demonstrated between OSAS and hypertension. Nowadays, the most efficient treatment of the OSAS is the continuous Positive Airway Pressure (cPAP). Several studies have also shown that cPAP could reduce arterial blood pressure in OSAS patients. But level of blood pressure (BP), drug treatment were not equal between groups and it's difficult to single out independent role of cPAP. Our study has the objective to compare the effects of cPAP on hypertension in OSAS patients. After 3-9 weeks of antihypertensive treatment (valsartan and amlodipine) those one who reached target level of BP will be randomized either in the group "treatment by cPAP" or in the group "treatment by cham-cPAP" for 3 weeks and then we'll perform cross-over.

Conditions

• Obstructive Sleep Apnea Syndrome
• Hypertension

Interventions

Type	Name	Description
PROCEDURE	cPAP	After reaching target level of BP patients will be randomized in active group (cPAP) and control group (sham-cPAP)

Timeline

• Start date: 2008-09-01
• Primary completion: 2011-06-01
• Completion: 2011-06-01
• First posted: 2008-12-03
• Last updated: 2011-06-17

Locations

1 site across 1 country: Russia