NCT00800657

Stem Cells and Resynchronization Cardiac

Stem-Cells and Heart Failure in Several Ethiologies. Alternative Indication With Cardiac Resynchronization

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Instituto de Molestias Cardiovasculares · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

Same patients with dilated myocardiopathies with large areas of fibrosis has not been as successful after Cardiac Resynchronization Therapy, for Heart Failure patients in functional class III or IV. Therefore the investigators have decided to associate the Stem-Cell implant with Cardiac Resynchronization Therapy in these patients.

Detailed description

About 120cc of blood are collected from the iliac bone marrow under epidural anesthesia.In the cell therapy lab this blood is harvested and mononuclear cells are separated.This procedure takes roughly 4 hours.After dilution the mononuclear cells are injected into the cardiac muscles with fibroses area through 20 shots.This procedure is indicated for patients with cardiac ischemia and left ventricular dysfunction(desynchrony), on whom all the others known therapies have failed.

Conditions

• Heart Failure

Interventions

Type	Name	Description
PROCEDURE	Pacing and Stem Cells Implantations.	Implantation of Cardiac Ressyncrhonization combined with the implantation of Stem Cells Hematopoietics.
PROCEDURE	Pacing and Stem Cells Implantation	Pacing and Stem Cells Implantation.

Timeline

• Start date: 2008-11-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2008-12-02
• Last updated: 2011-06-23

Locations

1 site across 1 country: Brazil