NCT00797589

Effect of Prime Solution on Fluid Balance After Open Heart Surgery

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: University of Helsinki · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The use of Tetraspan® as prime solution can reduce fluid extravasation after perfusion versus Ringer acetate. Plasma-adapted HES-solutions produce also less acidosis.

Detailed description

Fifty patients scheduled for elective primary and single cardiac surgery include in this prospective study. Patients with preoperative coagulation disorders, or renal or hepatic failure, are excluded. Before admission to the operation theatre, the patients allocate in random order to receive one of the following solutions during the extracorporeal circulation: 1. Ringer-acetate solution 2. 6% HES solution (Tetraspan®) During the 1 postoperative day we register hemodynamic changes, fluid balance, fluid extravasation, plasma ion concentration, modified thromboelastography, and kidney function.

Conditions

• Valve Surgery
• Coronary Artery Bypass Grafting

Interventions

Type	Name	Description
DRUG	HES	20ml/kg as prime fluid
DRUG	Ringer lactate

Timeline

• Start date: 2009-01-01
• Primary completion: 2012-09-01
• Completion: 2012-09-01
• First posted: 2008-11-25
• Last updated: 2015-08-25

Locations

1 site across 1 country: Finland