NCT00797407

Effectiveness of Creatine in Preventing Muscle Aching From Cholesterol-Lowering Statin Drugs

Creatine Supplementation for the Prevention of Statin Myalgia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: The Cleveland Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine of creatine will prevent or treat the muscle toxicity side effect of statin drug therapy, whose symptoms are aching, cramping, and weakness. This is tested in patients who have had this side effect from 3 different statin drugs.

Detailed description

Muscle toxicity is the most common limiting side effect of statin therapy. Biochemical studies have suggested the presence of intramuscular creatine deficiency in patients with muscle toxicity. This is a test of oral creatine supplementation in statin intolerant subjects as a method of preventing the onset of this side effect as well as resolving these symptoms when present during statin therapy.

Conditions

• Hypercholesterolemia
• Aches
• Cramps
• Weakness

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Creatine	Creatine 5 gm orally twice a day for 5 days, followed by 5 gm once a day

Timeline

• Start date: 2006-08-01
• Primary completion: 2006-12-01
• Completion: 2006-12-01
• First posted: 2008-11-25
• Last updated: 2008-11-25

Locations

1 site across 1 country: United States