NCT00795964

Influence of Tidal Volume on Postoperative Pulmonary Function

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 101 (actual)
• Sponsor: Heinrich-Heine University, Duesseldorf · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

Lung function impairment is common after abdominal surgery. Few preventive strategies exist against postoperative lung function impairment. A new potential preventive strategy against postoperative lung function impairment comes from research on critically ill patients with severe respiratory failure. In this field research has long focused on influence of breathing volume (= tidal volume) during mechanical ventilation on outcome. It has been shown, that low tidal volumes improve patients outcomes as compared to (conventional) high tidal volumes. Therefore, we propose a patient and investigator blinded randomised trial to test the hypotheses that intraoperative mechanical ventilation with low tidal volumes as compared to high tidal volumes reduces postoperative lung function impairment in high risk patients.

Conditions

• Pulmonary Function

Interventions

Type	Name	Description
OTHER	Randomized application of intraoperative tidal volume	intraoperative mechanical ventilation with 6 ml/kg predicted body weight
OTHER	Randomized application of intraoperative tidal volume	intraoperative mechanical ventilation with 12 ml/kg predicted body weight

Timeline

• Start date: 2008-09-01
• Primary completion: 2010-09-01
• Completion: 2010-09-01
• First posted: 2008-11-21
• Last updated: 2010-09-24

Locations

1 site across 1 country: Germany