NCT00795496

Bronchial Hyperreactivity in Atopic Dermatitis Patients - a 10 Year Follow-up

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: University of Helsinki · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The investigators will contact 64 patients with atopic dermatitis (AD) who participated in a long-term tacrolimus ointment trial in Helsinki 10 years ago, and ask them to participate in this follow-up study. The investigators will do the same tests as 10 years ago, i.e. bronchial hyperreactivity, skin prick tests, serum-IgE, Mantoux-test (2 TU), and questionnaires about asthma and allergic rhinitis symptoms. The investigators also collect data about their AD medication during the last 10 years. The investigators hypothesis is that when the skin condition improves in patients with AD the brochial hyperreactivity improves. The investigators also want to study whether different treatments play a role in the development or resolution of bronchial hyperreactivity.

Detailed description

We will by letters and telephone contact all patients (n=64) who fulfill the inclusion criteria for this study. The testing in the study (bronchial hyperreactivity, skin prick testing, serum IgE) is cross-sectional, but we retrospectively collect data from the last 10 years about the skin condition and medication for atopic diseases.

Conditions

• Atopic Dermatitis

Interventions

Type	Name	Description
PROCEDURE	Histamine provocation	A dosimetric histamine challenge test in which the provocative dose of inhaled histamine producing a decrease of 15% in FEV1 is measured.
PROCEDURE	Skin prick tests	Skin prick testing will be performed for: birch, timothy, mugwort, alder, pine, cat, dog, horse, house dust mite, Cladosporium herbarum.
PROCEDURE	Serum IgE blood testing	One blood test to measure total serum IgE
PROCEDURE	Mantoux-testing	Tuberculin (2 TU) s.c. on the forearm. The test is read after 72 hours.

Timeline

• Start date: 2008-11-01
• Primary completion: 2010-04-01
• Completion: 2010-08-01
• First posted: 2008-11-21
• Last updated: 2011-04-20

Locations

1 site across 1 country: Finland